Sertraline is indicated for the treatment of symptoms of depression, including depression accompanied by symptoms of anxiety, in patients with or without a history of mania.
Following satisfactory response, continuation with sertraline therapy is effective in preventing relapse of the initial episode of depression or recurrence of further depressive episodes.
Sertraline is indicated for the treatment of obsessive-compulsive disorder (OCD).
Following satisfactory response, continuation with sertraline therapy is effective in preventing relapse of the initial episode of OCD.
Sertraline is indicated for the treatment of pediatric patients with OCD.
Sertraline is indicated for the treatment of panic disorder, with or without agoraphobia.
Following satisfactory response, continuation with sertraline therapy is effective in preventing relapse of the initial episode of panic disorder.
Sertraline is indicated for the treatment of post-traumatic stress disorder (PTSD).
Following satisfactory response, continuation with sertraline therapy is effective in preventing relapse of initial episode of PTSD.
Sertraline is indicated for the treatment of social phobia (social anxiety disorder).
Following satisfactory response, continuation with sertraline therapy is effective in preventing relapse of the initial episode of social phobia.

Dosage in Patients with MDD, OCD, PD, PTSD, and SAD
The recommended initial dosage and maximum SERTRALINE dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below. A dosage of 25 mg or 50 mg per day is the initial therapeutic dosage.
For adults and pediatric patients, subsequent dosages may be increased in case of an inadequate response in 25 to 50 mg per day increments once a week, depending on tolerability, up to a maximum of 200 mg per day. Given the 24-hour elimination half-life of SERTRALINE, the recommended interval between dose changes is one week.

Sertraline potentiates serotonergic activity in the central nervous system through inhibition of neuronal reuptake of serotonin (5-HT).