Transplant Care

Introduction

Introduction to Transplant Care

Non-communicable (chronic) diseases (NCDs) impose a substantial burden on health-care systems, economies, quality of life, employment status and social activities1

Chronic Kidney Disease

700 million Estimated global prevalence of CKD2

~735,000 Deaths globally due to CKD3

151-232/million population Estimated Prevalence of ESRD in India4
1.5 billion Estimated global prevalence of chronic liver disease5

2 million global liver disease–related deaths5

259,749 liver disease deaths in India6

18.3% Global liver disease - related deaths in 20157

Organ transplantation could be the best therapy for terminal and irreversible organ failure8

  • Organ transplantation
    • improves patient survival1
    • improves quality of life1
    • has a beneficial impact on public health and the socio-economic burden of organ failure1
    • Renal transplantation increases patient survival over dialysis9

    References:

    1. Vanholder R, Domínguez-Gil B, Busic M, et al. Organ donation and transplantation: a multi-stakeholder call to action. Nat Rev Nephrol. 2021;17(8):554-568. doi:10.1038/s41581-021-00425-3
    2. Cockwell P, Fisher LA. The global burden of chronic kidney disease. Lancet. 2020 Feb 29;395(10225):662-664. doi: 10.1016/S0140-6736(19)32977-0. Epub 2020 Feb 13. 
    3. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the global burden of disease study 2010. Lancet. 2012;380:2095–128
    4. Modi G, Jha V. Incidence of ESRD in India. Kidney Int. 2011;79:573
    5. Moon AM, Singal AG, Tapper EB. Contemporary epidemiology of chronic liver disease and cirrhosis. Clin Gastroenterol Hepatol 2020;18:2650-2666
    6. Mishra D, Dash KR, Khatua C, et al. A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha. Euroasian J Hepatogastroenterol. 2020;10(1):1-6. doi:10.5005/jp-journals-10018-1312
    7. Mokdad AA, Lopez AD, Shahraz S, et al. Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Med 2014;18:145
    8. Grinyó JM. Why is organ transplantation clinically important?. Cold Spring Harb Perspect Med. 2013;3(6):a014985. Published 2013 Jun 1. doi:10.1101/cshperspect.a014985
    9. Kaballo MA, Canney M, O'Kelly P, Williams Y, O'Seaghdha CM, Conlon PJ. A comparative analysis of survival of patients on dialysis and after kidney transplantation. Clin Kidney J. 2018;11(3):389-393. doi:10.1093/ckj/sfx117